Prooxidant/Antioxidant Balance in Hypoxia: A Cross-Over Study on Normobaric vs. Hypobaric “Live High-Train Low”

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Title: Prooxidant/Antioxidant Balance in Hypoxia: A Cross-Over Study on Normobaric vs. Hypobaric “Live High-Train Low”
Authors: Debevec, Tadej | Pialoux, Vincent | Saugy, Jonas J. | Schmitt, Laurent | Cejuela Anta, Roberto | Mury, Pauline | Ehrström, Sabine | Faiss, Raphael | Millet, Grégoire P.
Research Group/s: Grupo de Investigación en Ciencias de la Actividad Física y el Deporte (GICAFD)
Center, Department or Service: Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas
Keywords: Live High-Train Low | Prooxidant/Antioxidant Balance | Hypoxia | Normobaric | Hypobaric
Knowledge Area: Educación Física y Deportiva
Issue Date: 14-Sep-2015
Publisher: Public Library of Science (PLoS)
Citation: Debevec T, Pialoux V, Saugy J, Schmitt L, Cejuela R, Mury P, et al. (2015) Prooxidant/Antioxidant Balance in Hypoxia: A Cross-Over Study on Normobaric vs. Hypobaric “Live High-Train Low”. PLoS ONE 10(9): e0137957. doi:10.1371/journal.pone.0137957
Abstract: “Live High-Train Low” (LHTL) training can alter oxidative status of athletes. This study compared prooxidant/antioxidant balance responses following two LHTL protocols of the same duration and at the same living altitude of 2250 m in either normobaric (NH) or hypobaric (HH) hypoxia. Twenty-four well-trained triathletes underwent the following two 18-day LHTL protocols in a cross-over and randomized manner: Living altitude (PIO2 = 111.9 ± 0.6 vs. 111.6 ± 0.6 mmHg in NH and HH, respectively); training “natural” altitude (~1000–1100 m) and training loads were precisely matched between both LHTL protocols. Plasma levels of oxidative stress [advanced oxidation protein products (AOPP) and nitrotyrosine] and antioxidant markers [ferric-reducing antioxidant power (FRAP), superoxide dismutase (SOD) and catalase], NO metabolism end-products (NOx) and uric acid (UA) were determined before (Pre) and after (Post) the LHTL. Cumulative hypoxic exposure was lower during the NH (229 ± 6 hrs.) compared to the HH (310 ± 4 hrs.; P<0.01) protocol. Following the LHTL, the concentration of AOPP decreased (-27%; P<0.01) and nitrotyrosine increased (+67%; P<0.05) in HH only. FRAP was decreased (-27%; P<0.05) after the NH while was SOD and UA were only increased following the HH (SOD: +54%; P<0.01 and UA: +15%; P<0.01). Catalase activity was increased in the NH only (+20%; P<0.05). These data suggest that 18-days of LHTL performed in either NH or HH differentially affect oxidative status of athletes. Higher oxidative stress levels following the HH LHTL might be explained by the higher overall hypoxic dose and different physiological responses between the NH and HH.
Sponsor: The study was funded by grants from the Ministère des Sports, de la Jeunesse, de l’Education Populaire et de la Vie Associative (MSJEPVA; France; to L.S. and G.P.M.), Institut National du Sport, de l’Expertise et de la Performance (INSEP; France; to L.S. and G.P.M.) and Institut Universitaire de France (IUF; France; to V.P.).
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0137957
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2015 Debevec et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Peer Review: si
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Appears in Collections:INV - GICAFD - Artículos de Revistas
INV - RIPEFAP - Artículos de Revistas

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