Role of IFN-gamma in immune responses to Candida albicans infections

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Title: Role of IFN-gamma in immune responses to Candida albicans infections
Authors: Gozalbo, Daniel | Maneu, Victoria | Gil, María Luisa
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Center, Department or Service: Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía
Keywords: Candida albicans | Candidiasis | Infection | IFN-gamma | Review
Knowledge Area: Farmacología
Issue Date: 1-Jun-2014
Publisher: Frontiers in Bioscience
Citation: Frontiers in Bioscience (Landmark Ed.). 2014, 19: 1279-1290. doi:10.2741/4281
Abstract: Candida albicans is the most frequent etiologic agent that causes opportunistic fungal infections called candidiasis, a disease whose systemic manifestation could prove fatal and whose incidence is increasing as a result of an expanding immunocompromised population. Here we review the role of interferon-gamma (IFN-γ) in host protection against invasive candidiasis. This cytokine plays an essential role in both the innate and adaptive arms of the immune response to candidiasis. We focus on recent progress on host-pathogen interactions leading to the production of IFN-γ by host cells. IFN-γ is produced by CD4 Th1, CD8, γδ T, and natural killer (NK) cells, essentially in response to both IL-12 and/or IL-18; more recently, a subset of C. albicans-specific Th17 cells have been described to produce both IL-17 and IFN-γ. IFN-γ plays an important role in the regulation of the immune system as well as in the control of the infectious process, as it is required for optimal activation of phagocytes, collaborates in the generation of protective antibody response, and favors the development of a Th1 protective response.
Sponsor: Research in the M.L. Gil and D. Gozalbo laboratory is supported by Grant SAF2010-18256 (Ministerio de Economia y Competitividad, Spain).
ISSN: 1093-9946 (Print) | 1093-4715 (Online)
DOI: 10.2741/4281
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2014 Frontiers in Bioscience
Peer Review: si
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Appears in Collections:INV - NEUROVIS - Artículos de Revistas

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