Synthesis of N-aryl imidazoles catalyzed by copper nanoparticles on nanosized silica-coated maghemite

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Title: Synthesis of N-aryl imidazoles catalyzed by copper nanoparticles on nanosized silica-coated maghemite
Authors: Nador, Fabiana | Volpe, María A. | Alonso, Francisco | Radivoy, Gabriel
Research Group/s: Nuevos Materiales y Catalizadores (MATCAT)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: Copper nanoparticles | Magnetic catalyst | Maghemite | C–N cross-coupling | N-arylation | Imidazole
Knowledge Area: Química Orgánica
Issue Date: 9-Sep-2014
Publisher: Elsevier
Citation: Tetrahedron. 2014, 70(36): 6082-6087. doi:10.1016/j.tet.2014.04.003
Abstract: A magnetically recoverable catalyst consisting of copper nanoparticles (CuNPs) on nanosized silica-coated maghemite is presented. The catalyst has been prepared under mild conditions by mixing the magnetic support with a freshly prepared suspension of CuNPs obtained by fast reduction of anhydrous CuCl2 with lithium sand and a catalytic amount of DTBB (4,4′-di-tert-butylbiphenyl) as electron carrier. This copper-based catalyst has shown to be very efficient in the N-(hetero)arylation of imidazole using (hetero)aryl bromides and iodides as arylating agents under ligand-free conditions. The catalyst is easily recovered by means of an external magnet and can be reutilized in three N-arylation cycles without apparent loss of catalytic activity.
Sponsor: This work was generously supported by the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Project PIP 738, Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) Project PICT 2010 e 669 e Prest. BID and Universidad Nacional del Sur (UNS) Project PGI 24/Q044.
ISSN: 0040-4020 (Print) | 1464-5416 (Online)
DOI: 10.1016/j.tet.2014.04.003
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2014 Elsevier Ltd.
Peer Review: si
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Appears in Collections:INV - MATCAT - Artículos de Revistas

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