Catalytic Enantioselective Addition of Aryl Grignard Reagents to Ketones

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Title: Catalytic Enantioselective Addition of Aryl Grignard Reagents to Ketones
Authors: Fernández Mateos, Emilio | Maciá Ruiz, Beatriz | Yus, Miguel
Research Group/s: Síntesis Asimétrica (SINTAS) | Nuevos Materiales y Catalizadores (MATCAT)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: Synthetic methods | Homogeneous catalysis | Grignard reaction | Enantioselectivity | Ketones | Titanium
Knowledge Area: Química Orgánica
Issue Date: Oct-2014
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
Citation: European Journal of Organic Chemistry. 2014, 29: 6519-6526. doi:10.1002/ejoc.201402935
Abstract: We report a catalytic system for the challenging enantioselective addition of aryl Grignard reagents to ketones. Using a simple, one-pot procedure under mild conditions, a wide range of aromatic ketones are converted into diaryl alcohols in good yields and with good enantioselectivities.
Sponsor: The authors acknowledge financial support from the Spanish Ministerio de Ciencia y Tecnología (MCYT) (project numbers CTQ2007-65218/BQU and CTQ2011-24151), Consolider Ingenio 2010 (grant number CSD2007-00006), and Generalitat Valenciana (G. V. PROMETEO/2009/039 and FEDER). B. M. thanks the European Commision for a Marie Curie Career Integration Grant. E. F.-M. thanks the Ministerio de Educación y Ciencia (MEC) for a FPU predoctoral fellowship (AP-2010-2926).
ISSN: 1434-193X (Print) | 1099-0690 (Online)
DOI: 10.1002/ejoc.201402935
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Peer Review: si
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Appears in Collections:INV - SINTAS - Artículos de Revistas
INV - MATCAT - Artículos de Revistas

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