Ultrasonic tissue characterization for monitoring nanostructured TiO2 induced bone growth
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Título: | Ultrasonic tissue characterization for monitoring nanostructured TiO2 induced bone growth |
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Autor/es: | Garcia-Martinez, Javier | Rus Carlborg, Guillermo |
Grupo/s de investigación o GITE: | Nanotecnología Molecular |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Inorgánica | Universidad de Granada. Departamento de Mecánica de Estructuras |
Palabras clave: | Inverse problem | Elastography | Ultrasonics | Tissue characterization | Implant | Nanostructured | Titania | Ultrasonic monitoring |
Área/s de conocimiento: | Química Inorgánica |
Fecha de creación: | 2006 |
Fecha de publicación: | may-2007 |
Editor: | IOP Publishing |
Cita bibliográfica: | GARCÍA MARTÍNEZ, Javier; RUS CARLBORG, Guillermo. "Ultrasonic tissue characterization for monitoring nanostructured TiO2 induced bone growth". Physics in Medicine and Biology. Vol. 52, No. 12 (21 June 2007). ISSN 0031-9155, pp. 3531-3547 |
Resumen: | The use of bioactive nanostructured TiO2 has recently been proposed for improving orthopaedic implant adhesion due to its improved biocompatibility with bone, since it induces: (i) osteoblast function, (ii) apatite nucleation and (iii) protein adsorption. The present work focuses on a non-ionizing radiation emitting technique for quantifying in real time the improvement in terms of mechanical properties of the surrounding bone due to the presence of the nanostructured TiO2 prepared by controlled precipitation and acid ageing. The mechanical strength is the ultimate goal of a bone implant and is directly related to the elastic moduli. Ultrasonics are high frequency mechanical waves and are therefore suited for characterizing elastic moduli. As opposed to echographic techniques, which are not correlated to elastic properties and are not able to penetrate bone, a low frequency ultrasonic transmission test is proposed, in which a P-wave is transmitted through the specimen and recorded. The problem is posed as an inverse problem, in which the unknown is a set of parameters that describe the mechanical constants of the sequence of layers. A finite element numerical model that depends on these parameters is used to predict the transformation of the waveform and compare to the measurement. The parameters that best describe the real tissue are obtained by minimizing the discrepancy between the real and numerically predicted waveforms. A sensitivity study to the uncertainties of the model is performed for establishing the feasibility of using this technique to investigate the macroscopic effect on bone growth of nanostructured TiO2 and its beneficial effect on implant adhesion. |
Patrocinador/es: | Generalitat Valenciana (grant INV05-10) |
URI: | http://hdl.handle.net/10045/4473 |
ISSN: | 0031-9155 (Print) | 1361-6560 (Online) |
DOI: | 10.1088/0031-9155/52/12/013 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | Copyright © Institute of Physics and IOP Publishing Limited |
Revisión científica: | si |
Versión del editor: | http://dx.doi.org/10.1088/0031-9155/52/12/013 |
Aparece en las colecciones: | INV - NANOMOL - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
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Guillermo.pdf | Versión final (acceso restringido) | 1,23 MB | Adobe PDF | Abrir Solicitar una copia |
232548Rev13Apr07.pdf | Borrador revisado (acceso libre) | 914,45 kB | Adobe PDF | Abrir Vista previa |
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