Analytical model of ionization and energy deposition by proton beams in subcellular compartments

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Título: Analytical model of ionization and energy deposition by proton beams in subcellular compartments
Autor/es: Vera Gomis, Pablo de | Surdutovich, Eugene | Abril, Isabel | García Molina, Rafael | Solov'yov, Andrey V.
Grupo/s de investigación o GITE: Interacción de Partículas Cargadas con la Materia
Centro, Departamento o Servicio: Universidad de Alicante. Departamento de Física Aplicada
Palabras clave: Analytical model | Ionization | Energy deposition | Proton beams | Subcellular compartments
Área/s de conocimiento: Física Aplicada
Fecha de publicación: abr-2014
Editor: EDP Sciences | Società Italiana di Fisica | Springer
Cita bibliográfica: The European Physical Journal D. 2014, 68: 96. doi:10.1140/epjd/e2014-50041-7
Resumen: We present an analytical model to evaluate in a fast, simple and effective manner the energy delivered by proton beams moving through a cell model made of nucleus and cytoplasm, taking into account the energy carried by the secondary electrons generated along the proton tracks. The electronic excitation spectra of these subcellular compartments have been modelled by means of an empirical parameterization of their dielectric properties. The energy loss rate and target ionization probability induced by swift protons are evaluated by means of the dielectric formalism. With the present model we have quantified the energy delivered, the specific energy, and the number of ionizations produced per incoming ion in a typical human cell by a typical hadrontherapy proton beam having energies usually reached around the Bragg peak (below 20 MeV). We find that the specific energy per incoming ion delivered in the nucleus and in the cytoplasm are rather similar for all the proton energy range analyzed.
Patrocinador/es: The authors acknowledge financial support from the Spanish Ministerio de Economía y Competitividad and the European Regional Development Fund (Project No. FIS2010-17225). Support from the European COST Action MP-1002, Nanoscale insights into ion beam cancer therapy, is also gratefully acknowledged. P.d.V. thanks the Conselleria d’Educació, Cultura i Esport de la Generalitat Valenciana for its support under the VALi+d program, and the COST Action MP-1002 for travel grants.
URI: http://hdl.handle.net/10045/37753
ISSN: 1434-6060 (Print) | 1434-6079 (Online)
DOI: 10.1140/epjd/e2014-50041-7
Idioma: eng
Tipo: info:eu-repo/semantics/article
Derechos: © EDP Sciences, Società Italiana di Fisica, Springer-Verlag 2014
Revisión científica: si
Versión del editor: http://dx.doi.org/10.1140/epjd/e2014-50041-7
Aparece en las colecciones:INV - IPCM - Artículos de Revistas

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