Chiral β-amino alcohols as ligands for the ruthenium-catalyzed asymmetric transfer hydrogenation of N-phosphinyl ketimines

Please use this identifier to cite or link to this item: http://hdl.handle.net/10045/34358
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dc.contributorSíntesis Asimétrica (SINTAS)es
dc.contributorCatálisis Estereoselectiva en Síntesis Orgánica (CESO)es
dc.contributor.authorPablo, Óscar-
dc.contributor.authorGuijarro, David-
dc.contributor.authorYus, Miguel-
dc.contributor.otherUniversidad de Alicante. Departamento de Química Orgánicaes
dc.date.accessioned2013-12-04T09:17:05Z-
dc.date.available2013-12-04T09:17:05Z-
dc.date.issued2012-01-09-
dc.identifier.citationApplied Sciences. 2012, 2(1): 1-12. doi:10.3390/app2010001es
dc.identifier.issn2076-3417-
dc.identifier.urihttp://hdl.handle.net/10045/34358-
dc.description.abstractSome chiral β-amino alcohols have been evaluated as potential ligands for the ruthenium-catalyzed asymmetric transfer hydrogenation (ATH) of N-phosphinyl ketimines in isopropyl alcohol. The ruthenium complex prepared from [RuCl2(p-cymene)]2 and (1S,2R)-1-amino-2-indanol has shown to be an efficient catalyst for the ATH of several N-(diphenylphosphinyl)imines, affording the reduction products in very good isolated yields and enantiomeric excesses up to 82%. The inherent rigidity of the indane ring system present in the ligand seems to be very important to achieve good enantioselectivities.es
dc.description.sponsorshipThis work was generously supported by the Spanish Ministerio de Ciencia e Innovación (MICINN; Grant No. CONSOLIDER INGENIO 2010, CSD2007-00006, CTQ2007-65218, and CTQ11-24151) and the Generalitat Valenciana (PROMETEO/2009/039 and FEDER). Óscar Pablo thanks the Spanish Ministerio de Educación for a predoctoral fellowship (Grant No. AP2008-00989).es
dc.languageenges
dc.publisherMDPIes
dc.rights© 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).es
dc.subjectN-(diphenylphosphinyl)iminees
dc.subjectAsymmetric transfer hydrogenationes
dc.subjectRuthenium catalystes
dc.subjectβ-amino alcoholes
dc.subjectIsopropyl alcoholes
dc.subject.otherQuímica Orgánicaes
dc.titleChiral β-amino alcohols as ligands for the ruthenium-catalyzed asymmetric transfer hydrogenation of N-phosphinyl ketimineses
dc.typeinfo:eu-repo/semantics/articlees
dc.peerreviewedsies
dc.identifier.doi10.3390/app2010001-
dc.relation.publisherversionhttp://dx.doi.org/10.3390/app2010001es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
Appears in Collections:INV - CESO - Artículos de Revistas
INV - SINTAS - Artículos de Revistas

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