Enantioselective direct aldol reaction: the blossoming of modern organocatalysis
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Title: | Enantioselective direct aldol reaction: the blossoming of modern organocatalysis |
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Authors: | Guillena, Gabriela | Nájera, Carmen | Ramón, Diego J. |
Research Group/s: | Derivados de Aminoácidos y Péptidos en Síntesis Orgánica | Procesos Catalíticos en Síntesis Orgánica |
Center, Department or Service: | Universidad de Alicante. Departamento de Química Orgánica |
Keywords: | Organocatatysis | Aldol | Enantioselective | Asymmetric synthesis | Amino acids | Proline |
Knowledge Area: | Química Orgánica |
Issue Date: | 27-Sep-2007 |
Publisher: | Elsevier |
Citation: | GUILLENA TOWNLEY, Gabriela; NÁJERA DOMINGO, Carmen; RAMÓN DANGLA, Diego José. "Enantioselective direct aldol reaction: the blossoming of modern organocatalysis". Tetrahedron: Asymmetry. Vol. 18, Issue 19 (27 Sept. 2007). ISSN 0957-4166, pp. 2249-2293 |
Abstract: | The use of simple (S)-proline as catalyst for the intermolecular direct aldol reaction at the beginning of this century became a true milestone in the growth of organocatalysis as a useful synthetic strategy. Since then, a plethora of new organocatalytic systems have been developed allowing to reach extraordinary levels of efficiencies, widening the scope of substrates used. Several modifications have been introduced to overcome some of the initial drawbacks, such as long reaction times, high catalyst loading, excess of reagents, etc., improving the expectations for their use in large scale synthesis. All these achievements would not be possible without a partial understanding of the involved mechanism. The acquired knowledge in this area has allowed the application of this strategy to be used in the synthesis of natural products. Within this review, a comprehensive look of all these aspects will be discussed. |
Sponsor: | We are grateful to the Spanish Ministerio de Educación y Ciencia, as well as to Generalitat Valenciana and University of Alicante, for their continuous financial support. |
URI: | http://hdl.handle.net/10045/2468 |
ISSN: | 0957-4166 |
DOI: | 10.1016/j.tetasy.2007.09.025 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Peer Review: | si |
Publisher version: | http://dx.doi.org/10.1016/j.tetasy.2007.09.025 |
Appears in Collections: | INV - DAPSO - Artículos INV - PCSO - Artículos de Revistas INV - MATCAT - Artículos de Revistas INV - AMIC - Artículos de Revistas INV - SINTAS - Artículos de Revistas INV - CESO - Artículos de Revistas |
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File | Description | Size | Format | |
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aldol.pdf | Versión final (acceso restringido) | 791,72 kB | Adobe PDF | Open Request a copy |
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