Repeated sequence homogenization between the control and pseudo-control regions in the mitochondrial genomes of the subfamily Aquilinae

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Title: Repeated sequence homogenization between the control and pseudo-control regions in the mitochondrial genomes of the subfamily Aquilinae
Authors: Cadahía Lorenzo, Luis | Pinsker, Wilhelm | Negro Balmaseda, Juan José | Pavlicev, Mihaela | Urios, Vicente | Haring, Elisabeth
Research Group/s: Zoología de Vertebrados
Center, Department or Service: Universidad de Alicante. Departamento de Ciencias Ambientales y Recursos Naturales
Keywords: Mitochondrial genomes | Raptors | Aquilinae | Control region | Pseudo-control region | Homogenization
Knowledge Area: Zoología
Issue Date: 9-Feb-2009
Publisher: Wiley-Liss, Inc.
Citation: CADAHÍA, Luis, et al. "Repeated sequence homogenization between the control and pseudo-control regions in the mitochondrial genomes of the subfamily Aquilinae". Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. Vol. 312B, Issue 3 (15 May 2009). ISSN 1552-5007, pp. 171-185
Abstract: In birds, the noncoding control region (CR) and its flanking genes are the only parts of the mitochondrial (mt) genome that have been modified by intragenomic rearrangements. In raptors, two noncoding regions are present: the CR has shifted to a new position with respect to the “ancestral avian gene order,” whereas the pseudo-control region (ΨCR) is located at the original genomic position of the CR. As possible mechanisms for this rearrangement, duplication and transposition have been considered. During characterization of the mt gene order in Bonelli's eagle Hieraaetus fasciatus, we detected intragenomic sequence similarity between the two regions supporting the duplication hypothesis. We performed intra- and intergenomic sequence comparisons in H. fasciatus and other falconiform species to trace the evolution of the noncoding mtDNA regions in Falconiformes. We identified sections displaying different levels of similarity between the CR and ΨCR. On the basis of phylogenetic analyses, we outline an evolutionary scenario of the underlying mutation events involving duplication and homogenization processes followed by sporadic deletions. Apparently, homogenization may easily occur if sufficient sequence similarity between the CR and ΨCR exists. Moreover, homogenization itself allows perpetuation of this continued equalization, unless this process is stopped by deletion. The Pandionidae and the Aquilinae seem to be the only two lineages of Falconiformes where homology between both regionsis still detectable, whereas in other raptors no similarity was found so far. In these two lineages, the process of sequence degeneration may have slowed down by homogenization events retaining high sequence similarity at least in some sections.
Sponsor: Terra Natura Foundation; European Synthesys program; Grant number: AT-TAF-2434; Government of the Comunidad Valenciana; Spanish Ministry of Education and Science; Grant number: AP2001-1444.
URI: http://hdl.handle.net/10045/22724
ISSN: 1552-5007 (Print) | 1552-5015 (Online)
DOI: 10.1002/jez.b.21282
Language: eng
Type: info:eu-repo/semantics/article
Rights: The definitive version is available at www3.interscience.wiley.com
Peer Review: si
Publisher version: http://dx.doi.org/10.1002/jez.b.21282
Appears in Collections:INV - ZV - Artículos Científicos

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