Intraretinal processing following photoreceptor rescue by non-retinal cells

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dc.contributorNeurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)en
dc.contributor.authorPinilla Lozano, Isabel-
dc.contributor.authorCuenca, Nicolás-
dc.contributor.authorMartínez Navarrete, Gema Concepción-
dc.contributor.authorLund, Raymond D.-
dc.contributor.authorSauvé, Yves-
dc.contributor.otherUniversidad de Alicante. Departamento de Fisiología, Genética y Microbiologíaen
dc.identifier.citationPINILLA LOZANO, Isabel, et al. "Intraretinal processing following photoreceptor rescue by non-retinal cells". Vision Research. Vol. 49, Issue 16 (12 Aug. 2009). ISSN 0042-6989, pp. 2067-2077en
dc.identifier.issn0042-6989 (Print)-
dc.identifier.issn1878-5646 (Online)-
dc.description.abstractRoyal College of Surgeon (RCS) rats undergo retinal degeneration due to the inability of retinal pigment epithelial (RPE) cells to phagocytose shed outer segments. We explored the effect of introducing Schwann cells to the subretinal space of RCS rats (before the onset of retinal degeneration), by relying on electro-retinogram (ERG) recordings and correlative retinal morphology. Scotopic ERGs recorded from cell-injected eyes showed preserved amplitudes of mixed a-wave b-wave, rod b-waves, and cone b-waves over controls (sham-injected eyes); photopic b-wave amplitudes and critical flicker fusion were also improved. Normal retinal morphology was found in areas of retinas that had received cell injections. Since Schwann cells have no phagocytic properties, their therapeutic effect is best explained through a paracrine mechanism (secretion of factors that ensure photoreceptor survival).en
dc.description.sponsorshipThis work was supported by FFB (Foundation Fighting Blindness), Wynn Foundation, Lincy Grant and RPB Grants. Dr. Cuenca and Dr. Pinilla were supported by a grant from the Spanish Government (BFU2006-00957/BFI, RETICS RD07/0062/0012 and Fundaluce for NC and FIS 02/5010 for IP). Dr. Sauvé is a recipient of the Barbara Tuck/MacPhee Family Vision Research Award in Macular Degeneration and an AHFMR Senior Scholar.en
dc.subjectRetinal dystrophyen
dc.subjectRCS ratsen
dc.subjectCell-based therapyen
dc.titleIntraretinal processing following photoreceptor rescue by non-retinal cellsen
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