Intraretinal processing following photoreceptor rescue by non-retinal cells

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Title: Intraretinal processing following photoreceptor rescue by non-retinal cells
Authors: Pinilla Lozano, Isabel | Cuenca, Nicolás | Martínez Navarrete, Gema Concepción | Lund, Raymond D. | Sauvé, Yves
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Center, Department or Service: Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología
Keywords: Retinal dystrophy | RCS rats | Cell-based therapy | Photoreceptors | Electroretinogram
Knowledge Area: Oftalmología
Issue Date: 2-Jun-2009
Publisher: Elsevier
Citation: PINILLA LOZANO, Isabel, et al. "Intraretinal processing following photoreceptor rescue by non-retinal cells". Vision Research. Vol. 49, Issue 16 (12 Aug. 2009). ISSN 0042-6989, pp. 2067-2077
Abstract: Royal College of Surgeon (RCS) rats undergo retinal degeneration due to the inability of retinal pigment epithelial (RPE) cells to phagocytose shed outer segments. We explored the effect of introducing Schwann cells to the subretinal space of RCS rats (before the onset of retinal degeneration), by relying on electro-retinogram (ERG) recordings and correlative retinal morphology. Scotopic ERGs recorded from cell-injected eyes showed preserved amplitudes of mixed a-wave b-wave, rod b-waves, and cone b-waves over controls (sham-injected eyes); photopic b-wave amplitudes and critical flicker fusion were also improved. Normal retinal morphology was found in areas of retinas that had received cell injections. Since Schwann cells have no phagocytic properties, their therapeutic effect is best explained through a paracrine mechanism (secretion of factors that ensure photoreceptor survival).
Sponsor: This work was supported by FFB (Foundation Fighting Blindness), Wynn Foundation, Lincy Grant and RPB Grants. Dr. Cuenca and Dr. Pinilla were supported by a grant from the Spanish Government (BFU2006-00957/BFI, RETICS RD07/0062/0012 and Fundaluce for NC and FIS 02/5010 for IP). Dr. Sauvé is a recipient of the Barbara Tuck/MacPhee Family Vision Research Award in Macular Degeneration and an AHFMR Senior Scholar.
URI: http://hdl.handle.net/10045/16722
ISSN: 0042-6989 (Print) | 1878-5646 (Online)
DOI: 10.1016/j.visres.2009.05.014
Language: eng
Type: info:eu-repo/semantics/article
Peer Review: si
Publisher version: http://dx.doi.org/10.1016/j.visres.2009.05.014
Appears in Collections:INV - NEUROVIS - Artículos de Revistas

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