Intraretinal processing following photoreceptor rescue by non-retinal cells

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Títol: Intraretinal processing following photoreceptor rescue by non-retinal cells
Autors: Pinilla Lozano, Isabel | Cuenca, Nicolás | Martínez Navarrete, Gema Concepción | Lund, Raymond D. | Sauvé, Yves
Grups d'investigació o GITE: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Centre, Departament o Servei: Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología
Paraules clau: Retinal dystrophy | RCS rats | Cell-based therapy | Photoreceptors | Electroretinogram
Àrees de coneixement: Oftalmología
Data de publicació: 2-de juny-2009
Editor: Elsevier
Citació bibliogràfica: PINILLA LOZANO, Isabel, et al. "Intraretinal processing following photoreceptor rescue by non-retinal cells". Vision Research. Vol. 49, Issue 16 (12 Aug. 2009). ISSN 0042-6989, pp. 2067-2077
Resum: Royal College of Surgeon (RCS) rats undergo retinal degeneration due to the inability of retinal pigment epithelial (RPE) cells to phagocytose shed outer segments. We explored the effect of introducing Schwann cells to the subretinal space of RCS rats (before the onset of retinal degeneration), by relying on electro-retinogram (ERG) recordings and correlative retinal morphology. Scotopic ERGs recorded from cell-injected eyes showed preserved amplitudes of mixed a-wave b-wave, rod b-waves, and cone b-waves over controls (sham-injected eyes); photopic b-wave amplitudes and critical flicker fusion were also improved. Normal retinal morphology was found in areas of retinas that had received cell injections. Since Schwann cells have no phagocytic properties, their therapeutic effect is best explained through a paracrine mechanism (secretion of factors that ensure photoreceptor survival).
Patrocinadors: This work was supported by FFB (Foundation Fighting Blindness), Wynn Foundation, Lincy Grant and RPB Grants. Dr. Cuenca and Dr. Pinilla were supported by a grant from the Spanish Government (BFU2006-00957/BFI, RETICS RD07/0062/0012 and Fundaluce for NC and FIS 02/5010 for IP). Dr. Sauvé is a recipient of the Barbara Tuck/MacPhee Family Vision Research Award in Macular Degeneration and an AHFMR Senior Scholar.
URI: http://hdl.handle.net/10045/16722
ISSN: 0042-6989 (Print) | 1878-5646 (Online)
DOI: 10.1016/j.visres.2009.05.014
Idioma: eng
Tipus: info:eu-repo/semantics/article
Revisió científica: si
Versió de l'editor: http://dx.doi.org/10.1016/j.visres.2009.05.014
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