Assessment of the organocatalytic activity of chiral l-Proline-based Deep Eutectic Solvents based on their structural features
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Title: | Assessment of the organocatalytic activity of chiral l-Proline-based Deep Eutectic Solvents based on their structural features |
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Authors: | Tiecco, Matteo | Alonso, Diego A. | Ros Ñíguez, Diego | Ciancaleoni, Gianluca | Guillena, Gabriela | Ramón, Diego J. | Apio Bonillo, Alberto | Germani, Raimondo |
Research Group/s: | Catálisis Estereoselectiva en Síntesis Orgánica (CESO) | Alternative Methodologies In Chemistry (AMIC) |
Center, Department or Service: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
Keywords: | Deep Eutectic Solvents | Enantioselectivity | Green chemistry | Asymmetric organocatalysis | Active solvents |
Knowledge Area: | Química Orgánica |
Issue Date: | 1-Sep-2020 |
Publisher: | Elsevier |
Citation: | Journal of Molecular Liquids. 2020, 313: 113573. doi:10.1016/j.molliq.2020.113573 |
Abstract: | The impact on the environment of polluting and volatile organic solvents represents nowadays a severe problem. In order to reduce the incidence on the environment of chemical applications, Deep Eutectic Solvents (DESs) represent a step ahead in this field thanks to their green properties. These novel liquids are formed by inter- and intra-molecular weak interactions between two species and they are synthesized by simply heating and mixing them without any solvent. These solvents also show interesting catalytic capabilities, since their properties are truly tuneable. In this paper, l-Proline-based Chiral Deep Eutectic Solvents (CDESs) were prepared and used as green and organocatalytic reaction media in a probe asymmetric Michael addition; in this reaction the l-Proline acts as solvent component as well as chiral organocatalyst. The results were analysed with NMR studies taking in account the availability of the l-Proline, considering the strength of the association of it with the counterpart of the liquids. With DFT studies, the geometry and energy of the adducts are shown and a qualitative rationale to the reaction stereoisomers distribution is given. |
Sponsor: | This work was supported by the University of Pisa through the PRA_2018_36 grant, and by the Spanish Ministerio de Ciencia, Innovación y Universidades (MICINN, PGC2018-096616-B-I00) and the University of Alicante (VIGROB-173). |
URI: | http://hdl.handle.net/10045/107418 |
ISSN: | 0167-7322 (Print) | 1873-3166 (Online) |
DOI: | 10.1016/j.molliq.2020.113573 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © 2020 Elsevier B.V. |
Peer Review: | si |
Publisher version: | https://doi.org/10.1016/j.molliq.2020.113573 |
Appears in Collections: | INV - CESO - Artículos de Revistas INV - AMIC - Artículos de Revistas |
Files in This Item:
File | Description | Size | Format | |
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Tiecco_etal_2020_JMolecularLiquids_final.pdf | Versión final (acceso restringido) | 1,31 MB | Adobe PDF | Open Request a copy |
Tiecco_etal_2020_JMolecularLiquids_accepted.pdf | Accepted Manuscript (acceso abierto) | 1,46 MB | Adobe PDF | Open Preview |
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